{
  "glossaryTerms": [
    {
      "term": "acupuncture",
      "definition": "a method of producing analgesia or altering the function of a body system by inserting fine, wire-thin needles into the skin at specific body sites along a series of lines, or channels, called meridians<sup>32</sup>",
      "audioFileName": "acupuncture.mp3"
    },
    {
      "term": "coronary heart disease",
      "definition": "a disease in which there is narrowing or blockage of the coronary arteries (blood vessels that carry blood and oxygen to the heart); may cause chest pain, shortness of breath during exercise, and heart attacks<sup>33</sup>",
      "audioFileName": "coronary_heart_disease.mp3"
    },
    {
      "term": "esters",
      "definition": "a class of chemical compounds formed by the bonding of an alcohol and one or more organic acids, with the loss of a water molecule for each ester group formed<sup>32</sup>",
      "audioFileName": "esters.mp3"
    },
    {
      "term": "estradiol",
      "definition": "the principal estrogen secreted in the ovaries and also the most biologically active; among the human estrogens, only estradiol is available in a government-approved single estrogen product; estradiol levels steeply decline during the first year of menopause, followed by a more gradual decline<sup>1,5</sup>",
      "audioFileName": "estradiol.mp3"
    },
    {
      "term": "estrogen",
      "definition": "one of a group of hormonal steroid compounds that promote the development of female secondary sex characteristics; the estrogens produced in the human body are estradiol, estrone, and estriol<sup>5,32</sup>",
      "audioFileName": "estrogen.mp3"
    },
    {
      "term": "estrone",
      "definition": "estrone is metabolized from estradiol; it is also 50% to 70% less biologically active than estradiol; in postmenopause, the dominant circulating type of estrogen is estrone<sup>2,5</sup>",
      "audioFileName": "estrone.mp3"
    },
    {
      "term": "exogenous",
      "definition": "originating outside the body or an organ of the body or produced from external causes<sup>32</sup>",
      "audioFileName": "exogenous.mp3"
    },
    {
      "term": "hormone",
      "definition": "one of many substances made by glands in the body that circulates in the bloodstream and controls the actions of certain cells or organs; some hormones can also be made in the laboratory<sup>34</sup>",
      "audioFileName": "hormone.mp3"
    },
    {
      "term": "hot flashes",
      "definition": "a sudden, temporary onset of body warmth, flushing, and sweating; often associated with menopause<sup>34</sup>",
      "audioFileName": "hot_flashes.mp3"
    },
    {
      "term": "hyperplasia",
      "definition": "an increase in the number of cells in an organ or tissue; the cells appear normal under a microscope and are not cancer, but may become cancer<sup>34</sup>",
      "audioFileName": "hyperplasia.mp3"
    },
    {
      "term": "menopause",
      "definition": "the permanent end of menstruation; a woman is diagnosed as having entered menopause after she has not had a menstrual cycle for 12 consecutive months<sup>1,2</sup>",
      "audioFileName": "menopause.mp3"
    },
    {
      "term": "night sweats",
      "definition": "nocturnal sweating by a woman as an effect of menopause or perimenopause (hot flashes that occur at night); may be mild or profuse enough to disrupt sleep<sup>32</sup>",
      "audioFileName": "night_sweats.mp3"
    },
    {
      "term": "person-years",
      "definition": "a statistical measure representing one person at risk of development of a disease during a period of one year<sup>32</sup>",
      "audioFileName": "person_years.mp3"
    },
    {
      "term": "progesterone",
      "definition": "a type of hormone made by the body that plays a role in the menstrual cycle and pregnancy<sup>35</sup>",
      "audioFileName": "progesterone.mp3"
    },
    {
      "term": "progestin",
      "definition": "any natural or laboratory-made substance that has some or all of the biologic effects of progesterone<sup>35</sup>",
      "audioFileName": "progestin.mp3"
    },
    {
      "term": "selective estrogen receptor modulator (SERM)",
      "definition": "a drug that acts like estrogen on some tissues but blocks the effect of estrogen on other tissues<sup>22</sup>",
      "audioFileName": "selective_estrogen_receptor_modulator.mp3"
    },
    {
      "term": "serotonin",
      "definition": "a hormone found in the brain, platelets, digestive tract, and pineal gland that acts as both a neurotransmitter and a vasoconstrictor<sup>22</sup>",
      "audioFileName": "serotonin.mp3"
    },
    {
      "term": "steroid",
      "definition": "any of a group of fats that have a certain chemical structure; examples include sex hormones, cholesterol, bile acids, and some drugs<sup>22</sup>",
      "audioFileName": "steroid.mp3"
    },
    {
      "term": "testosterone",
      "definition": "a hormone made mainly in the testes and needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth<sup>36</sup>",
      "audioFileName": "testosterone.mp3"
    },
    {
      "term": "venous thromboembolism (VTE)",
      "definition": "a condition in which a blood clot forms within a vein<sup>32</sup>",
      "audioFileName": "venous_thromboembolism.mp3"
    }
  ]
}